Scandinavian journal of gastroenterology (2014 Jan)
issue 1 p. 84-91 (issn:1502-7708)
DNA topoisomerase I is a putative biomarker of irinotecan efficacy with clinical associations previously demonstrated at the protein level. The purpose of the present study was to perform the first clinical investigation of the association between the DNA topoisomerase I gene (TOP1) copy number and objective response following irinotecan treatment in patients with metastatic colorectal cancer.
Forfattere: Nygård SB, Christensen IJ, Nielsen SL, Nielsen HJ, Brünner N, Spindler KL