Artikler iht.:
Tidlig diagnose af Tarmkræft

 

Evaluation of a 92 multiplex protein panel in detection of colorectal cancer and high-risk adenoma in 784 symptomatic individuals.

Rasmussen L, Nielsen HJ, Christensen IJ

Cancer biomarkers : section A of Disease markers (2021 May) issn:1875-8592)

 

Age-stratified reference intervals unlock the clinical potential of circulating cell-free DNA as a biomarker of poor outcome for healthy individuals and patients with colorectal cancer.

Ørntoft MW, Jensen SØ, Øgaard N,Henriksen TV,Ferm L,Christensen IJ,Reinert T, Larsen OH, Nielsen HJ,Andersen CL

International journal of cancer (2021 Apr) Issue 7 p. 1665-1675 issn:1097-0215)

 

Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer.

Young GP, Symonds EL, Nielsen HJ, Ferm L, Christensen IJ, Dekker E, van der Vlugt M, Mallant-Hent RC, Boulter N, Yu B, Chan M, Tevz G, LaPointe LC, Pedersen SK

Clinical epigenetics (2021 01) Issue 1 p. 14 issn:1868-7083)

 

Early Detection and Recurrence of Colorectal Adenomas by Combination of Eight Cancer-Associated Biomarkers in Plasma.

Rasmussen L, Nielsen HJ, Christensen IJ

Clinical and experimental gastroenterology (2020 ) p. 273-284 issn:1178-7023)

 

Development of blood-based biomarker tests for early detection of colorectal neoplasia: Influence of blood collection timing and handling procedures

Lech Pedersen N, Mertz Petersen M, Ladd JJ, Lampe PD, Bresalier RS, Davis GJ, Demuth C, Jensen SØ, Andersen CL, Ferm L, Christensen IJ, Nielsen HJ

Clinica chimica acta; international journal of clinical chemistry (2020 Aug) p. 39-53 issn:1873-3492)

 

Enhanced Performance of DNA Methylation Markers by Simultaneous Measurement of Sense and Antisense DNA Strands after Cytosine Conversion.

Jensen SØ, Øgaard N, Nielsen HJ, Bramsen JB, Andersen CL

Clinical chemistry (2020 May) (issn:1530-8561)

 

Biomarkers for Early Detection of Colorectal Cancer:The Early Detection Research Network, a Framework for Clinical Translation.

Bresalier RS, Grady WM, Markowitz SD, Nielsen HJ, Batra SK, Lampe PD

A publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2020 Apr)
issn:1538-7755)

 

Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer.

Thorsen SF, Gromova I, Christensen IJ, Fredriksson S, Andersen CL, Nielsen HJ, Stenvang J, Moreira JMA

International journal of molecular sciences (2019 Dec)
Issue 23 issn:1422-0067)

 

Novel DNA methylation biomarkers show high sensitivity and specificity for blood-based detection of colorectal cancer-a clinical biomarker discovery and validation study.

Jensen SØ, Øgaard N, Ørntoft MW, Rasmussen MH, Bramsen JB, Kristensen H, Mouritzen P, Madsen MR, Madsen AH, Sunesen KG, Iversen LH, Laurberg S, Christensen IJ, Nielsen HJ, Andersen CL

Clinical epigenetics (2019 Nov)
Issue 1 p. 158 issn:1868-7083)

 

Evaluation of algorithm development approaches: Development of biomarker panels for early detection of colorectal lesions.

Gawel SH, Lucht M, Gomer H, Treado P, Christensen IJ, Nielsen HJ, Davis GJ,

Clinica chimica acta; international journal of clinical chemistry (2019 Aug)
p. 108-115 issn:1873-3492)

 

Genome-wide cell-free DNA fragmentation in patients with cancer

Cristiano S, Leal A, Phallen J, Fiksel J, Adleff V, Bruhm DC, Jensen SØ, Medina JE, Hruban C, White JR, Palsgrove DN, Niknafs N, Anagnostou V, Forde P, Naidoo J, Marrone K, Brahmer J, Woodward BD, Husain H, van Rooijen KL, Ørntoft MW, Madsen AH, van de Velde CJH, Verheij M, Cats A, Punt CJA, Vink GR, van Grieken NCT, Koopman M, Fijneman RJA, Johansen JS, Nielsen HJ, Meijer GA, Andersen CL, Scharpf RB, Velculescu VE

Nature (2019 Jun)
Issue 7761 p. 385-389 issn:1476-4687)

 

Increased serological, cancer-associated protein biomarker levels at diagnosis of large bowel adenoma:
Risk of subsequent primary malignancy?   

Piper TB, Jørgensen LN, Olsen J, Nielsen KT, Davis G, Johansen JS,Jarle Christensen I, Nielsen HJ

Acta Oncol. 2019 58(sup1):S42-S48. doi: 10.1080/0284186X.2018.1540885.
Epub 2018 Dec 7.

 

Triage for selection to colonoscopy

Mertz-Petersen m, Piper TB, Kleif J, Ferm L, Christensen IJ, Nielsen HJ

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (2018 10)
Issue 10 p. 1539-1541 issn:1532-2157)

 

Circulating cell-free nucleosomes as biomarkers for early detection of colorectal cancer

Rasmussen L, Christensen IJ, Herzog M, et al.

Oncotarget (2018 Feb)
Issue 12 p. 10247-10258 issn:1949-2553)

 

Direct detection of early-stage cancers using circulating tumor DNA.

Phallen J, Sausen M, Adleff V, Leal A, Hruban C, White J, Anagnostou V, Fiksel J, Cristiano S, Papp E, Speir S, Reinert T, Orntoft MW, Woodward BD, Murphy D, Parpart-Li S, Riley D, Nesselbush M, Sengamalay N, Georgiadis A, Li QK, Madsen MR, Mortensen FV, Huiskens J, Punt C, van Grieken N, Fijneman R, Meijer G, Husain H, Scharpf RB, Diaz LA, Jones S, Angiuoli S, Ørntoft T, Nielsen HJ, Andersen CL, Velculescu VE

Science translational medicine (2017 Aug) Issue 403 issn:1946-6242)

 

Discovery and validation of a colorectal cancer classifier in a new blood test with improved performance for high-risk subjects

Croner LJ, Dillon R, Kao A, Kairs SN, Benz R, Christensen IJ, Nielsen HJ, Blume JE, Wilcox B

Clinical proteomics (2017 ) p. 28 issn:1542-6416)

 

Serological biomarkers in triage of FIT-positive subjects?

Nielsen HJ, Christensen IJ, Andersen B, Rasmussen M, Friis-Hansen LJ, Bygott T, MiCallef J,

Scandinavian journal of gastroenterology (2017 Mar) p. 1-3 issn:1502-7708)

 

Detection of colorectal neoplasia: Combination of eight blood-based, cancer-associated protein biomarkers.

Wilhelmsen M, Christensen IJ, Rasmussen L, Jørgensen LN, Madsen MR, Vilandt J, Hillig T, Klaerke M, Nielsen KT, Laurberg S, Brünner N, Gawel S, Yang X, Davis G, Heijboer AM, Martens F, Nielsen HJ

International journal of cancer (2016 Dec) issn:1097-0215)

 

Protocol outlines for parts 1 and 2 of the prospective Endoscopy III study for the early detection of colorectal cancer: Validation of a concept based on blood biomarkers

Rasmussen L, Wilhelmsen M, Christensen IJ, Andersen J, Jørgensen LN, Rasmussen M, Hendel JW, Madsen MR, Vilandt J, Hillig T, Klærke M, Münster AM, Andersen LM, Andersen B, Hornung N, Erlandsen EJ, Khalid A, Nielsen HJ

JMIR research protocols (2016 ) Issue 3 p. e182 issn:1929-0748)

 

miRNA profiling of circulating EpCAM+ extracellular vesicles: Promising biomarkers of colorectal cancer

Ostenfeld MS, Jensen SG, Jeppesen DK, Christensen LL, Thorsen SB, Stenvang J, Hvam ML, Thomsen A, Mouritzen P, Rasmussen MH, Nielsen HJ, Ørntoft TF, Andersen CL

Journal of extracellular vesicles (2016 ) p. 31488

 

Increased serological cancer-associated biomarkers and risk of development of primary malignancy after large bowel endoscopy. 

Nielsen, HJ

Scand J Gastroenterol. 2016 Oct;51(10):1272. doi: 10.1080/00365521.2016.1195442. Epub 2016 Jun 16.

 

Pre-analytical variables of circulating cell-free nucleosomes containing 5-methylcytosine DNA or histone modification H3K9Me3.

Rasmussen L,  Herzog M.,  Rømer E.,  Micallef J,  Bulut O.,  Wilhelmsen M.,  Christensen I., Nielsen HJ.

Scand J Clin Lab Invest. 2016 Oct;76(6):448-53. doi: 10.1080/00365513.2016.1190862. Epub 2016 Jun 13.

 

Plasma levels of OLFM4 in normals and patients with gastrointestinal cancer.

Clemmensen SN, Glenthøj AJ, Heebøll S, Nielsen HJ, Koch C, Borregaard N.

J Cell Mol Med. 2015 Dec;19(12):2865-73. doi: 10.1111/jcmm.12679. Epub 2015 Sep 28.

 

Blood-based Biomarkers at Large Bowel Endoscopy and Prediction of Future Malignancies.

Kring TS, Piper TB, Jørgensen LN, Olsen J, Rahr HB, Nielsen KT, Laurberg S, Davis G, Dowell B, Johansen JS, Christensen IJ, Brünner N, Nielsen HJ.

Biomark Cancer. 2015 Oct 22;7:57-61. doi: 10.4137/BIC.S31330. eCollection 2015.

 

Performance of the colorectal cancer screening marker Sept9 is influenced by age, diabetes and arthritis: a nested case-control study.

Ørntoft MB, Nielsen HJ, Ørntoft TF, Andersen CL; Danish Study Group on Early Detection of Colorectal Cancer.

BMC Cancer. 2015 Oct 29;15:819. doi: 10.1186/s12885-015-1832-6.

 

Plasma TIMP-1 and CEA as Markers for Detection of Primary Colorectal Cancer: A Prospective Validation Study Including Symptomatic and Non-symptomatic Individuals.

Christensen IJ, Brünner N, Dowell B, Davis G, Nielsen HJ, Newstead G, King D.

Anticancer Res. 2015 Sep;35(9):4935-41.

 

Serum YKL-40 in risk assessment for colorectal cancer: a prospective study of 4,496 subjects at risk of colorectal cancer.

Johansen JS, Christensen IJ, Jørgensen LN, Olsen J, Rahr HB, Nielsen KT, Laurberg S, Brünner N, Nielsen HJ.

Cancer Epidemiol Biomarkers Prev. 2015 Mar;24(3):621-6. doi: 10.1158/1055-9965.EPI-13-1281. Epub 2015 Jan 18.

 

Evaluation of complement proteins as screening markers for colorectal cancer.

Storm L, Christensen IJ, Jensenius JC, Nielsen HJ, Thiel S; Danish Study Group on Early Detection of Colorectal Cancer.

Cancer Immunol Immunother. 2015 Jan;64(1):41-50. doi: 10.1007/s00262-014-1615-y. Epub 2014 Sep 27.

 

Circulating intact and cleaved forms of the urokinase-type plasminogen activator receptor: biological variation, reference intervals and clinical useful cut-points.

Thurison T, Christensen IJ, Lund IK, Nielsen HJ, Høyer-Hansen G.

Clin Chim Acta. 2015 Jan 15;439:84-90. doi: 10.1016/j.cca.2014.10.004. Epub 2014 Oct 13

 

Data fusion in metabolomic cancer diagnostics

Metabolomics : Official journal of the Metabolomic Society (2013 Feb) Issue 1 p. 3-8 issn:1573-3882)

 

Basis data for “Triage i screening for tarmkræft”:

Serological biomarkers in triage of FIT-positive subjects?
Nielsen HJ, Christensen IJ, Andersen B, Rasmussen M, Friis-Hansen LJ, Bygott T, MiCallef J; Danish–Belgian Research Group on Early Detection of Colorectal Cancer.Scand J Gastroenterol. 2017 Jun – Jul;52(6-7):742-744. doi: 10.1080/00365521.2017.1299212. Epub 2017 Mar 8.