Four Areas

Four Research Areas

including extensive international collaborations

with the aim to improve the prognosis of subjects diagnosed with CRC

 

 

Research areas:

 

What causes colorectal cancer?

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The aim is to identify a possible association between genetics in feces (bacterial, viral,
fungal DNA), blood and tumor tissue.

Specific toxins may lead to DNA mutations that eventually is the early onset of neoplasia leading to malignancy.

 

Early detection (screening)

Results of research based on blood testing have shown:circle-blue-en-2

  • Compliance rates > 90%
  • Significant detection of bowel neoplasia (benign as well as malignant)
  • Significant detection of extra-colonic malignancy

Screening based on blood testing may improve:

  • Compliance rates
  • Early detection of bowel malignancy = improved overall survival
  • Early detection of benign bowel neoplasia = reduced incidence of bowel malignancy
  • Frequency of testing that leads to improved early detection of neoplasia

 

Our present research projects:

 

Endoscopy III, part 1 and 2

Part 1
with a focus on identification, validation and implementation of a blood-based biomarker test for screening of large bowel neoplasia.
The project were associated to the current public screening offered to all Danish Citizens 50–74 years of age
from early 2014 to ultimo 2016.

Part 2—initiated in full in September 2016:
with the focus to be able to identify subjects who,although tested FIT negative,
may have bowel or extra-colonic neoplasia or alternatively
high risk of developing future neoplasia.

Blood samples and data are collected 3 times from 30,000 subjects
who have been screened FIT negative at 3 consecutive screening-rounds
—i.e. subsequent collections after 2 and 4 years, respectively
Estimated gain: 90,000 blood and subject data sets in total

The results from this project will be available by late 2023.

 

Triage in selection to diagnostic colonoscopy
of subjects with symptoms attributable to colorectal cancer (CRC):

From spring 2018 to ultimo 2020 our 3-step screening-concept
will be validated in use for a more accurate selection of only the neccessary colonoscopies
among subjects referred to diagnostic colonoscopy because of symptoms of CRC.

Due to the success of the CRC-screening in Denmark, the total need of colonoscopies has far exceeded the overall capacity.
Since approx. 70% of all colonoscopy show no treatment demanding findings
our TRIAGE-concept (= (1) a person’s age + (2) a FIT+- test (=test for occult blood in feces)  +  (3) a blood-based biomarker test)
are tested in use for also the selection of subjects with symptoms of CRC referred to diagnostic colonoscopy.

 

 

Early detection of recurrence

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The overall research has focus on identification, validation and implementation of a blood-based test concept that may detect recurrence early.

Early detection will lead to improved ability to institute renewed curative treatment—hence, improving the overall prognosis significantly.

 

Additional research

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Validation of preanalytical issues

Specific minor research studies focus on issues that may influence the proper interpretation of results achieved from the major, clinical studies
—including such as  procedures around blood collection, handling and storage, etc.

A continuous documentation and further qualification of our final results.

 

Contractual collaborations

Generated cooperative relations with national and international research groups,
including academic institutions and biotech companies,
lead to improved test options using the collaborators specifically invented analysis platforms.

Based on such collaborative approaches, we have achieved results
that play a significant role in the daily clinical routine and practice.

UK _FORSIDE_report_Side_1
Symposium August 2014

 

 

Read more:

Etiology of CRC      Early Detection      Early Detection Recurrence

 

Additional Research

 

 

 

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Contact:

ColoRectal Cancer Research

Gastroenheden, Hvidovre Hospital

Kettegård Allé 30

2650 Hvidovre

Email: info@colorectalcancer.dk