What causes development of CRC—
The etiology of CRC is still not known in detail.
It’s well-established, however,
that a cascade of DNA mutations in epithelial bowel cells play a significant role.
what causes such mutations..?—
and how does this relate to the well-established knowledge that food,
tobacco smoking, alcohol consumption, lack of physical activity, obesity, etc. also may play a major role..?
Why DNA mutations?—and subsequent cancer disease?
A new research area focuses on an etiology which based on DNA from fecal bacteria, vira and/or fungi in
interaction with specific fecal chemical substances may lead to severe DNA mutations and even damages
in the bowel epithelia due to toxins or incorporation of exoDNA into the human epithelial DNA.
Such events may initiate the development of early neoplasia,
which ultimately leads to development of malignancy.
Present research focuses on collection of data, feces, blood and tissue samples from patients undergoing resection for primary CRC.
To identify a possible association between
- Fecal exoDNA
- Development of toxins that lead to DNA mutation
- That initiates development of neoplasia – and ultimately development of CRC
- Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer. Gut 2015
These results are, presently, validated in a major: N=221—patient study with sequencing of blood, tissue and feces. [A Danish / Chinese collaboration].
- Topoisomerfase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers. Mol Oncol 2015;9:1207-17.