Etiology of CRC

What causes development of CRC—

  colorectal cancer?

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The etiology of CRC is still not known in detail.

It’s well-established, however,
that a cascade of DNA mutations in epithelial bowel cells play a significant role.

Question:

what causes such mutations..?—
and how does this relate to the well-established knowledge that food,
tobacco smoking, alcohol consumption, lack of physical activity, obesity, etc. also may play a major role..?

 

Why DNA mutations?—and subsequent cancer disease?

A new research area focuses on an etiology which based on DNA from fecal bacteria, vira and/or fungi in
interaction with specific fecal chemical substances may lead to severe DNA mutations and even damages
in the bowel epithelia due to toxins or incorporation of exoDNA into the human epithelial DNA.

Such events may initiate the development of early neoplasia,
which ultimately leads to development of malignancy.

Research

Present research focuses on collection of data, feces, blood and tissue samples from patients undergoing resection for primary CRC.

Aim

To identify a possible association between

  • Fecal exoDNA
  • Development of toxins that lead to DNA mutation
  • That initiates development of neoplasia – and ultimately development of CRC

 

Achieved results

Please see:

 

 

 

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Contact:

ColoRectal Cancer Research

Gastroenheden, Hvidovre Hospital

Kettegård Allé 30

2650 Hvidovre

Email: info@colorectalcancer.dk