Recent Results

Publications

“Triage for selection to colonoscopy?”Billedresultat for pdf ikon

See: www.doi.org/10.1016/j.ejso.2018.06.013 (advance publications July 2018)

Our results show that a triage concept could improve selection to colonoscopy.
The triage test including subject age, concentration of hemoglobin in a feces test and a
combination of certain blood-based cancer associated biomarkers
may reduce the requirements for colonoscopy by around 30%.
Advantageous results for the colonoscopy-capacity, the health budgets and in particular,
the subjects, who do not need an unnecessary, unpleasant and risk-associated bowel examination.

These results are achieved through several major clinical research projects focusing on blood markers for cancer. 

 

“Genome-wide cell-free DNA fragmentation in patients with cancer”

See: Nature 2019, Jun:570(7761);385-389

Our results show that a newly developed assay method can detect fragments of cell-free DNA in blood samples.
In healthy people, these fragments are predominantly derived from leukocytes, while the fragments
in cancer patients are, predominantly, tumor-derived.
This method is not nearly as complex as the previous methods of DNA analysis.
Proably, analyzes of even very large quantities can, by now, be carried out, as we are now testing.

The results also show that DNA fragments can be used for the detection of people with cancer—
and thus the method is likely to improve existing methods of blood-based DNA analysis for early detection of individuals with colorectalcancer.

 

“Direct detection of early-stage cancers using circulating tumor DNA”

See: Science Translational Medicine 2017;9:403

Our results show that DNA mutations in blood samples can identify 71% of those who carry an early stage colon cancer disease.
These results are generated in a collaboration between Johns Hopkins University, Baltimore, USA; MoMA, Skejby, DK—and collaborating hospitals in Denmark.

 

“Serological biomarkers in triage of FIT-positive subjects?”

See: Scandinavian Journal of Gastroenterology 2017;52:742-4

Age + a FIT-test + a blood test can identify individuals in risk of colon cancer
—who would bee missed in a bowel screening based on a Fit-test, alone

Our results show that a combination of a screening test for occult blood in stools (FIT), the person’s age plus
a biomarker-test based on blood with great accuracy will identify subjects with colon cancer or adenomas.

 

A result validation:

Biological markers in blood can detect subjects at risk of developing a future cancer disease

Our basic research-hypothesis is presently confirmed as we have shown that:
elevated levels of one or more of four blood-based biological markers relate to an increased risk of developing a cancer disease within few years

The design of our current major project ─ Endoscopy III, Part 2 (2016-2022) ─ is therefore based on the research hypothesis:

A screening with a stool test for occult blood showing “no findings” could be a “false negative response” as a malignant disease intra-or,extracolonic may already be under development (cf. a potential elevated biomarker level). Upon detection of an elevated biomarker level more frequent follow-ups should be offered to diagnose possible malignancy in early stages.

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Kontaktoplysninger

ColoRectal Cancer Research

Gastroenheden, Hvidovre Hospital

Kettegård Allé 30

2650 Hvidovre

Email: info@colorectalcancer.dk