Recent Results

Publications

“Triage for selection to colonoscopy?”Billedresultat for pdf ikon

See: www.doi.org/10.1016/j.ejso.2018.06.013 (advance publications July 2018)

Our results show that a triage concept could improve selection to colonoscopy.
The triage test including subject age, concentration of hemoglobin in a feces test and a
combination of certain blood-based cancer associated biomarkers
may reduce the requirements for colonoscopy by around 30%.
Advantageous results for the colonoscopy-capacity, the health budgets and in particular,
the subjects, who do not need an unnecessary, unpleasant and risk-associated bowel examination.

These results are achieved through several major clinical research projects focusing on blood markers for cancer. 

 

“Circulating cell-free nucleosomes as biomarkers
for 
early detection of colorectal cancer”

See: www.ncbi.nlm.nih.gov/pubmed/29535803

Our results show that we are likely to use DNA-associated components
for an early detection of colorectalcancer.
The combination of nucleosomes and protein CEA has a high specificity and moderate sensitivity in the identification of individuals with colorectalcancer.

 

“Direct detection of early-stage cancers using circulating tumor DNA”

See: Science Translational Medicine 2017;9:403

Our results show that DNA mutations in blood samples can identify 71% of those who carry an early stage colon cancer disease.These results are generated in a collaboration between Johns Hopkins University, Baltimore, USA; MoMA, Skejby, DK—and collaborating hospitals in Denmark and the Netherlands.

 

“Serological biomarkers in triage of FIT-positive subjects?”

See: Scandinavian Journal of Gastroenterology 2017;52:742-4

Age + a FIT-test + a blood test can identify individuals in risk of colon cancer
—who would bee missed in bowel screening based on a Fit-test, alone

Our results show that a combination of a screening test for occult blood in stools (FIT),
a biomarker-test based on blood and the person’s age with great accuracy will identify subjects with colon cancer or adenomas.

 

A result validation:

Biological markers in blood can detect subjects at risk of developing a future cancer disease

Our basic research-hypothesis is presently confirmed as we have shown that:
elevated levels of one or more of four blood-based biological markers relate to an increased risk of developing a cancer disease within few years

The design of our current major project ─ Endoscopy III, Part 2 (2016-2022) ─ is therefore based on the research hypothesis:

A screening with a stool test for occult blood showing “no findings” could be a “false negative response” as a malignant disease intra-or,extracolonic may already be under development (cf. a potential elevated biomarker level)─ hence, more frequent follow-up should be offered to diagnose malignancy in early stages.

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Kontaktoplysninger

ColoRectal Cancer Research

Gastroenheden, Hvidovre Hospital

Kettegård Allé 30

2650 Hvidovre

Email: info@colorectalcancer.dk