Triage in screening for colorectal cancer

Why

The current general screening for bowel cancer using an immunochemical test
for occult blood in feces (FIT) has led to identification of many subjects with bowel cancer
and extremely many with high-risk or medium-risk adenomas—a success
that’s generated by the number of subjects with positive FIT results.

In Denmark all subjects with a positive FIT result are offered subsequent colonoscopy.
Moreover, all subjects with a high-risk or medium-risk adenoma
are offered control colonoscopy after 1 and 3 years, respectively.

In addition, an increasing number of subjects are referred to diagnostic colonoscopy
due to symptoms that may be attributable to bowel cancer.

Hence, we now experience waiting times for colonoscopy in our treatment
far exceeding the statutory 14 days.
The total need for colonoscopies, currently, exceeds the total Danish investigation capacity.

A need that increases further as the screening range, from 2018,
will be reduced from the previous 4 years to 2 years.

 

Threshold limit value (cut-off)

In Denmark, the threshold value (cut-off) for the amount of occult blood in the feces,
which determines, whether a screened person is offered a subsequent colonoscopy,
is at 100 ng blood per ml stool.

Many European countries with CRC-screening have already been forced
to raise the cut-off value in order to adapt the demand for colonoscopy to the capacity.
Consequently, many subjects with adenoma lesions or the cancer
have not been identified through the general screening.

Among all colonoscopies, including: screening-derived colonoscopies;
diagnostic colonoscopies (due to symptoms of CRC); and control colonoscopies (due to adenoma control)
approx 50-70%  are without any findings of adenomas or actual disease.

Methods for a more accurate selection for colonoscopy of only those,
who are in real need of further examination
would help balancing needs with capacity─in favor of the health economics;
and also the individual, who avoids an unpleasant (non-risk-free) examination.

Our research results

Our research in blood-based cancer biomarkers shows:

  • That a blood-test can be crucial in identification of subjects
    with adenomas or the disease colorectal cancer.

Our research parallel to the general screening indicates:

  • That Triage used in CRC-screening─ie a combination of
    (1) age + (2) a stool-test (FIT) result + (3) a blood test—
    leads to a more precise selection to colonoscopy of those
    for whom a colonoscopy is required.
    Accordingly, the number of screening-derived colonoscopies
    will be reduced approximately 25%.

International research results
have recently shown that the FIT-test is suitable in selection
for diagnostic colonoscopy due to CRC-symptoms, as well.

Presumably, likewise use of the TRAIGE-concept in selection for diagnostic colonoscopy at CRC-symptoms
could reduce the total amount of needed diagnostic colonoscopies.

 

Triage in selection to diagnostic colonoscopy:

For the purpose of validating the options in using the TRIAGE concept for a more accurate selection
also for diagnostic colonoscopy among subjects with symptoms of CRC:
we have designed and will initiate a  3-year validation project from  spring of 2018.
The Endoscopy IV-project

 

Read more:
Application of research results

The publication on the basic research results: 
“Serological biomarkers in triage of FIT-positive subjects?”

See also:  Media-coverage
Videnskab.dk (30.11.16)  —  Jyllands-Posten (01.12.16) — BT (01.12.16

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Kontaktoplysninger

ColoRectal Cancer Research

Gastroenheden, Hvidovre Hospital

Kettegård Allé 30

2650 Hvidovre

Email: info@colorectalcancer.dk